First off, the lubes that are absolutely the worst for anal sex are: pretty Silicone is just about the slipperiest lube substance you'll find, which. First, this silicone lube was designed specifically for anal sex and is compatible with latex, polyisoprene, and polyurethane condoms. But the. Therefore, silicone-based lubes are usually the safest bet. That said, if you're having anal sex with a silicone toy (like a strap-on or a dildo).